The Streptococcus pyogenes serotype M49 Nra-Ralp3 Transcriptional Regulatory Network and its Control on Virulence Factor Expression from the Novel ERES Pathogenicity Region
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The Streptococcus pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity region.
Many Streptococcus pyogenes (group A streptococcus [GAS]) virulence factor- and transcriptional regulator-encoding genes cluster together in discrete genomic regions. Nra is a central regulator of the FCT region. Previous studies exclusively described Nra as a transcriptional repressor of adhesin and toxin genes. Here transcriptome and proteome analysis of a serotype M49 GAS strain and an isoge...
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تاریخ انتشار 2007